Asenapine (Sycrest)


Overview: Asenapine, known by the brand name Sycrest, is an antipsychotic of the Atypical class – the most frequently used class of antipsychotics. However, Asenapine is used mainly as a Mood Stabiliser. It is also sometimes used to treat Psychosis – mainly the mania phase of Bipolar Disorder. Asenapine has also been used for Schizophrenia before, though it is not licensed to do so in the United Kingdom. Asenapine has helped many people control their symptoms, and is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Asenapine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Asenapine, as mentioned below. Asenapine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Asenapine is used in conjunction with therapy.


Dosage: Asenapine comes in the form of a sublingual tablet. With these tablets you place the tablet underneath your tongue and wait for it to dissolve – it should only take a matter of seconds. Don’t swallow the tablet, or chew it. The normal dose is between 5mg and 10mg a day. It may take some time for the right dose to be found. Tablets should be taken twice a day – once in the morning and once in the evening. Do not eat or drink for ten minutes after taking the tablet. There is no set duration of treatment for Asenapine, with the course differing from patient to patient, dependent on circumstance and symptoms.


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Side Effects

With each box of Asenapine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Asenapine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Asenapine include anxiety, sleepiness, weight gain, restlessness, movement disorders, sedation, tremors, dizziness, increased saliva, fatigue.


Serious side effects include suicidal thinking, chest pain, movement disorders, seizures, jaundice, allergic reaction or fainting. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Asenapine. Do not use Asenapine with any Antidepressant. Ask your doctor for advice on combining Asenapine with any other medicine.


Do not take Asenapine if you have dementia.


Exert caution when using Asenapine if you have a history of heart problems, diabetes, Parkinson’s disease, epilepsy, dysphagia (difficulty swallowing), liver or kidney problems.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic doesn’t consume alcohol. Combining Asenapine with recreational drugs is also not recommended.


Asenapine is not recommended in pregnancy or the breastfeeding stage. It is believed that Asenapine can cause withdrawal symptoms in breastfed babies.


Other Atypical Antipsychotics: