Chlorpromazine (Largactil)


Overview: Chlorpromazine, known by the brand name Largactil, is an antipsychotic of the Typical class. Chlorpromazine is used to treat Psychosis – including Schizophrenia and Bipolar Disorder among other non-mental health conditions like ADHD and Vomiting. Chlorpromazine has helped many people control their symptoms. Chlorpromazine is only available on prescription. Chlorpromazine was the world’s first antipsychotic.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Chlorpromazine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Chlorpromazine, as mentioned below. Chlorpromazine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Chlorpromazine is used in conjunction with therapy.


Dosage: You should take Chlorpromazine three times a day. Achieve this by taking three 25mg tablets per day at regular intervals. You should take Chlorpromazine with water and without food. Alternatively, you can take a 75mg tablet once a day at bedtime. The dose might need to be titrated up slowly. A typical treatment course of Chlorpromazine varies from patient-to-patient.


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Side Effects

With each box of Chlorpromazine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Chlorpromazine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Chlorpromazine include a dry mouth, drowsiness and weight gain. Increased anxiety is also common.


Serious side effects include movements you can’t control, seizures, allergic reaction, suicidal thinking, swollen joints, jaundice, dark urine, high temperature and trembling. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Chlorpromazine. Do not use any antipsychotic with Tricyclic Antidepressants or Citalopram and Escitalopram. Antacids, epilepsy medicines, sedatives, amphetamines, cytotoxics, stimulants and Lithium shouldn’t be combined with Chlorpromazine.


Do not take Chlorpromazine if you suffer from Bone marrow depression, Glaucoma, Parkinson’s Disease or have a history of a low White blood cell count.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Chlorpromazine with recreational drugs is also not recommended.


Chlorpromazine is not recommended in pregnancy or the breastfeeding stage. It is believed that Chlorpromazine can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: