Flupentixol (Depixol)


Overview: Flupentixol, known by the brand name Depixol, is an antipsychotic of the Typical class. Flupentixol is used to treat Psychosis – mainly Schizophrenia. Flupentixol has helped many people control their symptoms. Flupentixol is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Flupentixol. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Flupentixol, as mentioned below. Flupentixol should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Flupentixol is used in conjunction with therapy.


Dosage: You can take Flupentixol in either tablet form or as an injection.


For the tablet form, you can take them with or without food – it won’t upset the stomach. The usual dose in an adult is 1 to 3 tablets, taken twice a day. Each tablet contains 3mg of Flupentixol. The maximum daily dose is 18mg.


However, if preferred, an injection can be given. The dosage of Flupentixol will be drawn up into a syringe, and will then be injected into the muscle of the buttock or thigh. The usual dosage for adults lies between 50mg once a month to 300mg once every two weeks. In rare cases, some patients will be given 400mg once a week. With larger doses, an injection might need to take place in two places. A test injection at a small dose will often be administered around a week before the first injection, to test tolerability. In any case, the medicine will be slowly released from the injection to match the effectiveness of the tablet dosage.


A typical treatment course of Flupentixol ranges from patient to patient, dependent on circumstance.


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Side Effects

With each box of Flupentixol, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Flupentixol can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Flupentixol include a dry mouth, drowsiness, muscle spasms and body rigidity. Appetite changes, dizziness, poor concentration, loss of libido, vomiting and tremors are also common. Please note this applies to both tablet and injection form.


Serious side effects include suicidal thinking, blood clot, high fever, tardive dyskinesia. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Flupentixol. Do not use any antipsychotic with Tricyclic Antidepressants. Don’t take Flupentixol if you have a heart condition, have severe breathing problems, liver or kidney problems, Parkinson’s Disease, Glaucoma, Diabetes, or take Corticosteroids.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Flupentixol with recreational drugs is also not recommended.


Flupentixol is not recommended in pregnancy or the breastfeeding stage. It is believed that Flupentixol can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: