Fluphenazine (Modecate)


Overview: Fluphenazine, known by the brand name Modecate, is an antipsychotic of the Typical class. Fluphenazine is used to treat Psychosis – including Schizophrenia. Fluphenazine has helped many people control their symptoms. Fluphenazine is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Fluphenazine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Fluphenazine, as mentioned below. Fluphenazine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Fluphenazine is used in conjunction with therapy.


Dosage: Fluphenazine is available in both tablet form and as an injection.


For the tablet form, the usual dose is anywhere from 2.5mg to 10mg daily. Tablets should be taken in divided doses every 6 to 8 hours, twice a day. You can take the tablets with or without food. The maximum dose of Fluphenazine is 40mg per day.


As mentioned, you can also have Fluphenazine administered via injection. Usually, Fluphenazine will be given every 2 to 5 weeks. The dose will be slowly released into the body – matching the potency of a tablet. The first dose given will be 12.5mg – this low dose will test the tolerability of the drug. This will be increased anywhere up to 100mg. Fluphenazine will be injected by a nurse or doctor into a muscle. Normally, the buttock muscle or thigh will be used.


A typical treatment course of Fluphenazine depends on the circumstance of the patient, and can last indefinitely if required.


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Side Effects

With each box of Fluphenazine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Fluphenazine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Fluphenazine include a drowsiness, tiredness, breast enlargement in men, sexual problems, insomnia, agitation, difficulty in urinating, blurred eyesight, dry mouth, constipation.


Serious side effects include suicidal thinking, jaundice, allergic reaction, high temperature, low temperature, movements that you can’t control, seizures, fast heartbeat or blood clots. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Fluphenazine. Do not use any antipsychotic with Tricyclic Antidepressants. Exert caution when using Fluphenazine with any antidepressant. You also shouldn’t use Fluphenazine with Quinine – the malaria drug. Always ask your doctor for any queries.


Do not take Fluphenazine if you have heart problems, liver or kidney problems, severe Depression, a blood disorder or have epilepsy or Parkinson’s Disease.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Fluphenazine with recreational drugs is also not recommended.


Fluphenazine is not recommended in pregnancy or the breastfeeding stage. It is believed that Fluphenazine can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: