Perphenazine (Fentazin)


Overview: Perphenazine, known by the brand name Fentazin, is an antipsychotic of the Typical class. Perphenazine is used to treat Psychosis – including Schizophrenia and the mania phase of Bipolar Disorder. It is also used for short-term treatment of Anxiety, Perphenazine has helped many people control their symptoms. Perphenazine is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Perphenazine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Perphenazine, as mentioned below. Perphenazine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Perphenazine is used in conjunction with therapy.


Dosage: Perphenazine can be taken with or without food. Swallow the tablets with water (don’t take them with tea or coffee). The normal dose of Perphenazine in adults is 4mg three times a day. You might start at a lower dose to see if you respond well to Perphenazine. The maximum daily dose is 24mg per day. Ensure you allow intervals of around 6-8 hours between each tablet. A typical treatment course of Perphenazine can range from patient to patient – dependent on circumstance.


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Side Effects

With each box of Perphenazine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Perphenazine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Perphenazine include a dry mouth, breast enlargement in men, tiredness, drowsiness, insomnia, constipation and weight gain.


Serious side effects include suicidal thinking and the serious movement disorder Tardive Dyskinesia. Swelling, difficulty in breathing, jaundice, blood clots and angina are other serious side effects. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Perphenazine. Do not use any antipsychotic with Tricyclic Antidepressants. Other medicines can act unpredictably with Perphenazine. You should exert caution when taking any antidepressant with Perphenazine. Sedatives, corticosteroids, strong pain killers, anticonvulsants and antacids shouldn’t be combined with Perphenazine. Always ask your doctor if you are unsure.


Don’t take Perphenazine if you have a blood disorder or low white blood cell count. If you have kidney or liver problems, or any heart-related disease, don’t take Perphenazine.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Perphenazine with  recreational drugs is also not recommended.


Perphenazine is not recommended in pregnancy or the breastfeeding stage. It is believed that Perphenazine can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: