Pimozide (Orap)


Overview: Pimozide, known by the brand name Orap, is an antipsychotic of the Typical class. Pimozide is used to treat Psychosis – mainly Schizophrenia. Pimozide has helped many people control their symptoms. While Pimozide is one of the older antipsychotics, it is actually used much more than some of the newer antipsychotics. In the event that an Atypical antipsychotic doesn’t work, Pimozide is a common second antipsychotic to try. Pimozide is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Pimozide. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Pimozide, as mentioned below. Pimozide should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Pimozide is used in conjunction with therapy.


Dosage: You should take Pimozide once a day. It doesn’t upset the stomach, and thus can be taken with or without food – although you should take the tablet with a glass of water. You should take the tablet at the same time each day. The usual dose of Pimozide in adults is 4mg per day, though a lower dose might be prescribed at the beginning. The maximum dose per day is 20mg. It can take some time to find the correct dose. A typical treatment course of Pimozide can range, depending on the circumstances and symptoms of a patient.


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Side Effects

With each box of Pimozide, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Pimozide can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Pimozide include excessive sweating, dizziness, drowsiness, restlessness, insomnia, lacking energy, a dry mouth, headache, blurred vision, weight gain, sexual dysfunction and excessive urinating.


Serious side effects include suicidal thinking, abnormally fast heartbeat, seizures, spasms or unusual movements. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Pimozide. Do not use Pimozide with any antidepressant unless directed specifically by your doctor. Medicines for your heart or allergies, Quinine, weight control medicines or medicines for digestive problems can all interact poorly with Pimozide.


Don’t take Pimozide if you have a history of heart problems, have Parkinson’s disease or are suffering from Depression. Exert caution if you have liver or kidney problems, have epilepsy, have had blood clots or have had a history of convulsions.


Do not drink grapefruit juice when taking Pimozide.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Pimozide with recreational drugs is also not recommended.


Pimozide is not recommended in pregnancy or the breastfeeding stage. It is believed that Pimozide can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: