Prochlorperazine (Stemetil)


Overview: Prochlorperazine, known by the brand name Stemetil, is an antipsychotic of the Typical class. Prochlorperazine is used to treat Psychosis – including Schizophrenia, and occasionally migraine headaches. Prochlorperazine has helped many people control their symptoms. Prochlorperazine is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Prochlorperazine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Prochlorperazine, as mentioned below. Prochlorperazine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Prochlorperazine is used in conjunction with therapy.


Dosage: Prochlorperazine is available in both tablet and injection form. However, the injection is rarely used outside of mental practices. For the tablet form, your dose for mental illness is normally 75-100mg a day. You are recommended to start at a low dose of 12.5mg, and slowly raise the dose weekly. Swallow the tablets with water. You should try and avoid touching the tablets as much as possible, as handling the tablets can cause blistered and sore skin.


Prochlorperazine is also available as an injection. The injection will allow Prochlorperazine to be slowly released into your body – allowing the same effect as tablets. However, as injections need to be administered two or three times a day by a doctor or nurse, realistically Prochlorperazine can only ever be administered in injection form in a controlled environment e.g. mental facility.


A typical treatment course of Prochlorperazine varies from patient to patient – dependent on the circumstance and symptoms.


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Side Effects

With each box of Prochlorperazine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Prochlorperazine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Prochlorperazine include sedation, restlessness, movement disorder, shaking and a dry mouth.


Serious side effects include suicidal thinking, blood clots, jaundice, movement disorders or difficulty in breathing. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Prochlorperazine. Do not use Prochlorperazine with any antidepressant. Some of the medicines that can interact poorly with Prochlorperazine include strong painkillers, anticholingernics, anaesthetics and heart medicines among others. Talk with your doctor regarding combining medicines.


Exert caution in taking Prochlorperazine if you have liver or kidney problems, ever had jaundice, have epilepsy, Parkinson’s disease or are elderly. Moreover, heart problems, alcohol abuse or dementia are all among the other problems that can affect Prochlorperazine.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Prochlorperazine with recreational drugs is also not recommended.


Prochlorperazine is not recommended in pregnancy or the breastfeeding stage. It is believed that Prochlorperazine can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: