Sulpiride (Sulpor)


Overview: Sulpiride, known by the brand name Sulpor, is an antipsychotic of the Typical class. Sulpiride is predominantly used to treat Psychosis – mainly Schizophrenia. However it can also be used as a supplementary medicine for Depression, and in a low dose – for Anxiety. Sulpiride has helped many people control their symptoms. Sulpiride is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Sulpiride. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Sulpiride, as mentioned below. Sulpiride should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Sulpiride is used in conjunction with therapy.


Dosage: Swallow Sulpiride tablets with a drink of water. The usual starting dose in adults is 400mg. This is normally achieved by taking two 200mg tablets each day – with an interval between them. The dose might be titrated up to a maximum of 800mg per day. A typical treatment course of Sulpiride ranges from patient to patient, dependent on symptoms and circumstance.


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Side Effects

With each box of Sulpiride, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Sulpiride can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication. However, Sulpiride is usually a well-tolerate drug, with few adverse effects.


Common side effects of Sulpiride include weight gain, painful breasts, drowsiness, sleepiness, insomnia, constipation and a dry mouth. Some shaking is common.


Serious side effects include suicidal thinking, tremors, seizures, movement disorders, blood clots, excessive shaking, muscle spasms, abnormally fast heartbeat or severe allergic reaction. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Sulpiride. Do not use any antipsychotic with Tricyclic Antidepressants. Tell your doctor if you are taking any of the following medicines – medicines for high blood pressure, Lithium, water tablets, laxatives, antibiotics, steroids, any antidepressant, stomach ulcer medication, allergy medication or Methadone. Always ask your doctor if you need clarification.


DO NOT take Levodopa – a medication for Parkinson’s Disease – with Sulpiride. When combined, the two can prove fatal.


Don’t take Sulpiride if you have Cancer or Parkinson’s Disease. Exert caution if you have anger problems, kidney or liver issues, a history of heart problems in your family, have low levels of potassium in your body, if you have dementia, epilepsy, high blood pressure or Glaucoma.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Sulpiride with  recreational drugs is also not recommended.


Sulpiride is not recommended in pregnancy or the breastfeeding stage. It is believed that Sulpiride  can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: