Trifluoperazine (Stelazine)


Overview: Trifluoperazine, known by the brand name Stelazine, is an antipsychotic of the Typical class. Trifluoperazine is used to treat Psychosis – primarily Schizophrenia. Trifluoperazine has helped many people control their symptoms. Trifluoperazine is only available on prescription. The use of Trifluoperazine has dramatically declined in recent years, but is still occasionally used.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Trifluoperazine. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Trifluoperazine, as mentioned below. Trifluoperazine should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Trifluoperazine is used in conjunction with therapy.


Dosage: Take Trifluoperazine with a glass of water, you can take it with or without food too. The normal dose for treating  Schizophrenia with Trifluoperazine is 10-15mg per day. Trifluoperazine comes in the form of 5mg tablets, and therefore you will either take two or three tablets a day – in any case with intervals. There is no set time on how long a treatment course of Trifluoperazine is – it will vary from patient to patient.


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Side Effects

With each box of Trifluoperazine, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Trifluoperazine can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Trifluoperazine include tardive dyskinesia (the serious movement disorder), drowsiness, dizziness, restlessness, insomnia, weight gain, dry mouth and blurred vision.


Serious side effects include suicidal thinking, abnormally fast heartbeat, jaundice, allergic reaction, angina, movement disorders and chest pain. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Trifluoperazine. Do not use Trifluoperazine with any Antidepressant. Tell your doctor if you are taking sleeping tablets, painkillers, anticonvulsants, medicines for Parkinson’s disease, medicines for iron poisoning, antacids and any heart medicine.


Do not take Trifluoperazine if you are suffering from liver or kidney problems, as well as jaundice. Exert caution when taking Trifluoperazine if you suffer from epilepsy, blood clots, high blood pressure, diabetes, smoke, drink excessive alchohol or have glaucoma.


You should not drink Alcohol while taking Trifluoperazine. Alcohol can enhance the sedative action of Trifluoperazine, and make you excessively drowsy. Combining Trifluoperazine with recreational drugs is also not recommended.


Trifluoperazine  is not recommended in pregnancy or the breastfeeding stage. It is believed that Trifluoperazine can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: