Zuclopenthixol (Clopixol)


Overview: Zuclopenthixol, known by the brand name Clopixol, is an antipsychotic of the Typical class. Zuclopenthixol is used to treat Psychosis – including Schizophrenia and the mania phase of Bipolar Disorder. Zuclopenthixol has helped many people control their symptoms. Zuclopenthixol is only available on prescription.


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Key Facts: It will take around four to six weeks for a patient to feel the full benefits of Zuclopenthixol. However, anxiety should lessen rapidly upon consumption of the drug. There are some side effects to Zuclopenthixol, as mentioned below. Zuclopenthixol should be used without interruption – you shouldn’t suddenly stop taking the medicine. The medicine should help control your symptoms.


How do they work?: Antipsychotics cannot help cure mental health conditions, but they are usually effective in reducing and controlling some of the symptoms associated with these conditions. These symptoms can include delusions and hallucinations, disturbed thoughts, agitation, mania and violence. The medication works by blocking the action of dopamine. It is believed psychotic episodes are caused by the brain producing too much of the chemical dopamine. The medication also regulates levels of other chemicals that are responsible for regulating mood – such as noradrenaline and serotonin. It is recommended that Zuclopenthixol is used in conjunction with therapy.


Dosage: You should take Zuclopenthixol with a glass of water. The starting dose is normally 20mg per day. The maximum dose of Zuclopenthixol is 150mg. Your dose will depend on the severity of your condition. In any case, tablets should be taken twice a day to achieve the targeted dose – your doctor will advise you how to proceed. The duration of the treatment can range enormously from patient to patient, dependent on a variety of circumstances. Zuclopenthixol can also come in the form of a long acting injection. In this case, injections can take place in three week intervals. Zuclopenthixol is sometimes used to heavily sedate an inpatient at a mental health facility.


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Side Effects

With each box of Zuclopenthixol, there will be an information leaflet enclosed. This will provide an exhaustive list of side effects. Side effects from Zuclopenthixol can last any length of time from just a few days to permanent changes. It is natural to experience some side effects as your body gets used to the medication.


Common side effects of Zuclopenthixol include a dry mouth, restlessness, drowsiness, headache, bruising, low blood pressure, weight gain, sexual dysfunction, breast enlargement in men.


Serious side effects include suicidal thinking, chest pain, jaundice, breathing difficulties, raised lumps on the skin and movement disorders. An overdose should be avoided. You should contact your doctor if any of these serious side effects take place.




You should always read the information leaflet that comes with your medication as it will include important information there. You should tell your doctor if you are taking any other medication. You shouldn’t use any other antipsychotic medication with Zuclopenthixol. Do not use any antipsychotic with Tricyclic Antidepressants. Some medicines that react unpredictably with Zuclopenthixol include anticoagulants, anticholingernics, Levodopa (for Parkinson’s disease), corticosteroids, medicines that lower blood pressure or medicines for epilepsy or diabetes.


Do not take Zuclopenthixol with any medicine that can alter the heartbeat e.g. Quinidine or Lithium.


Exert caution when taking Zuclopenthixol if you have a heart condition, liver or kidney problems, breathing problems, epilepsy, Parkinson’s disease, glaucoma, diabetes or blood clots.


Alcohol acts as a sedative, therefore it is recommended that anyone taking an antipsychotic stays away from drinking alcohol. Combining Zuclopenthixol with recreational drugs is also not recommended.


Zuclopenthixol is not recommended in pregnancy or the breastfeeding stage. It is believed that Zuclopenthixol can cause withdrawal symptoms in breastfed babies.


Other Typical Antipsychotics: